Transcriptional profiling of rat hypothalamus...

Abstract

In some mammals, halogenated aromatic hydrocarbon (HAH) exposure causes wasting syndrome, defined as significant weight loss associated with lethal outcomes. The most potent HAH in causing wasting is 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD), which exerts its toxic effects through the aryl hydrocarbon receptor (AHR). Since TCDD toxicity is thought to predominantly arise from dysregulation of AHR-transcribed genes, it was hypothesized that …

Authors

Houlahan KE; Prokopec SD; Moffat ID; Lindén J; Lensu S; Okey AB; Pohjanvirta R; Boutros PC

Journal

Toxicology, Vol. 328, , pp. 93–101

Publisher

Elsevier

Publication Date

2 2015

DOI

10.1016/j.tox.2014.12.016

ISSN

0300-483X

Associated Experts

Katie Houlahan

Assistant Professor, Faculty of Health Sciences

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Labels

Fields of Research (FoR)

3214 Pharmacology and pharmaceutical sciences 32 Biomedical and Clinical Sciences

Medical Subject Headings (MeSH)

Animals Cytochrome P-450 CYP1A1 Gene Expression Profiling Gene Expression Regulation Hypothalamus Male NAD(P)H Dehydrogenase (Quinone)Oligonucleotide Array Sequence Analysis Polychlorinated Dibenzodioxins RNA, Messenger Rats, Long-Evans Rats, Wistar Species Specificity Time Factors Toxicogenetics Transcription, Genetic Wasting Syndrome

Transcriptional profiling of rat hypothalamus response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin