Discovering and targeting vulnerabilities in invasive brain cancer using ROBO1 CAR T cells

Despite standard treatment efforts, patients with glioblastoma (GBM), an aggressive form of brain cancer, inevitably succumb to recurrent disease. Integrative genomic analyses reveal that tumor cells hijack normal neurodevelopmental pathways to promote GBM growth and invasion. To target this pathway, we engineer a CAR T cell therapy that blocks the growth of GBM and other invasive brain cancers.