Statistics as a scientific discipline of inquiry in the face of uncertainty, focuses on quantifications or information that is measureable. As stated by Rao (Statistics and truth: Putting chance to work, International Cooperative Publishing House, Fairland, MD, 1989), “all methods of acquiring knowledge are statistics.” Using as example the “motor vehicle-related accidents” problem, this chapter illustrates how the application of the principles and concepts of statistics can help one to have a better, and/or, an “educated understanding” of the problem. Four essential elements of statistical quantification in the field of injury prevention and control are specifically addressed in this chapter: (1) quantifying uncertainty, (2) quantifying probability, (3) quantifying risk and exposure, and (4) quantifying the strength of relationships. Each of these elements is explained and discussed in detail within the context of motor vehicle-related accidents.