Macrotermycins A–D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39 Journal Articles uri icon

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abstract

  • Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39's sequenced genome revealed the macrotermycin's putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had selective antifungal activity against a fungal parasite of the termite fungal garden.

authors

  • Beemelmanns, Christine
  • Ramadhar, Timothy R
  • Kim, Ki Hyun
  • Klassen, Jonathan L
  • Cao, Shugeng
  • Wyche, Thomas P
  • Hou, Yanpeng
  • Poulsen, Michael
  • Bugni, Tim S
  • Currie, Cameron
  • Clardy, Jon

publication date

  • March 3, 2017