Journal article
Macrotermycins A–D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39
Abstract
Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39's sequenced genome revealed the macrotermycin's putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had …
Authors
Beemelmanns C; Ramadhar TR; Kim KH; Klassen JL; Cao S; Wyche TP; Hou Y; Poulsen M; Bugni TS; Currie CR
Journal
Organic Letters, Vol. 19, No. 5, pp. 1000–1003
Publisher
American Chemical Society (ACS)
Publication Date
March 3, 2017
DOI
10.1021/acs.orglett.6b03831
ISSN
1523-7060