Journal article
Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides
Abstract
Three new dentigerumycin analogues are produced by Streptomyces sp. M41, a bacterium isolated from a South African termite, Macrotermes natalensis. The structures of the complex nonribosomal peptide synthetase-polyketide synthase (NRPS/PKS) hybrid compounds were determined by 1D- and 2D-NMR spectroscopy, high-resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Both cyclic and linear peptides are reported, and the genetic …
Authors
Wyche TP; Ruzzini AC; Beemelmanns C; Kim KH; Klassen JL; Cao S; Poulsen M; Bugni TS; Currie CR; Clardy J
Journal
Organic Letters, Vol. 19, No. 7, pp. 1772–1775
Publisher
American Chemical Society (ACS)
Publication Date
April 7, 2017
DOI
10.1021/acs.orglett.7b00545
ISSN
1523-7060