Evolution of a bispecific G-quadruplex-forming circular aptamer to block IL-6/sIL-6R interaction for inflammation inhibition Journal Articles uri icon

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abstract

  • We report a circular DNA aptamer isolated from a synthetic DNA library to bind both IL-6 and sIL-6R with nanomolar affinities. This aptamer can effectively block the IL-6/sIL-6R interaction and significantly inhibit cell inflammation.

authors

  • Yao, Lili
  • Wang, Lei
  • Liu, Shuai
  • Qu, Hao
  • Mao, Yu
  • Li, Yingfu
  • Zheng, Lei

publication date

  • August 14, 2024