No Association Between BMI and Immunotoxicity or Clinical Outcomes for Immune Checkpoint Inhibitors Journal Articles uri icon

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abstract

  • Background: The impact of BMI on immune checkpoint inhibitor toxicity and efficacy has not been clearly characterized. Methods: The authors conducted a retrospective single-center study of patients with advanced unresectable/metastatic cancer initiated on immune checkpoint inhibitors. Results: Of the 409 patients included in the study, 115 (28%) had a BMI ≥30. There was no difference in the development of immune-related adverse events, treatment response or overall survival with respect to BMI <30 versus ≥30 for the whole study population or the melanoma subgroup. Conclusion: Patients with BMI in the obese range (≥30) were not at increased risk of immunotoxicity. Furthermore, BMI was not correlated with treatment response or overall survival in patients receiving immune checkpoint inhibitors.

authors

  • Yeung, Cynthia
  • Kartolo, Adi
  • Holstead, Ryan
  • Moffat, Gordon Taylor
  • Hanna, Lilian
  • Hopman, Wilma
  • Baetz, Tara

publication date

  • July 2022