Improvement in protein separation using a modulated bipolar membrane chromatography technique

This paper discusses a novel method for improving resolution in protein separation obtained by membrane chromatography. The method is based on a bipolar membrane system involving the synergistic combination of a modulating membrane and a binding membrane for improving peak sharpness, and resolution in bind-and-elute protein separation. In this study, an anion exchange membrane served as the binding membrane while a cation exchange membrane …