Effect of leucine as an aerosolization enhancer on the bioactivity of spray dried viral-vectored vaccines for inhalation

We explore the advantages and disadvantages of l -leucine on spray dried vaccine formulations. Aerosolization enhancers, like l -leucine, can improve deep-lung deposition of inhalable dry powders although the implications of their use have not yet been evaluated for sensitive biologics like viral vectored vaccines. This study investigates the effect of l -leucine concentrations (0–50 wt%) as an added component to the viral-encapsulating …