Preprint
Improved Thermal Stabilization of VSV-Vector with Enhanced Vacuum Drying in Pullulan and Trehalose-Based Films
Abstract
One major limitation of effective vaccine delivery is its dependency on a robust cold chain infrastructure. While Vesicular stomatitis virus (VSV) has been demonstrated to be an effective viral vaccine vector for diseases including Ebola, its -70oC storage requirement is a significant limitation for accessing disadvantaged locations and populations. Previous work has shown thermal stabilization of viral vaccines with a combination of pullulan …
Authors
Iwashkiw JA; Mohamud AO; Kazhdan N; Ameen A; Beecher JE; Filipe CDM; Lichty BD
DOI
10.21203/rs.3.rs-4529092/v1
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