Association between serum estradiol and cardiovascular health among transgender adults using gender-affirming estrogen therapy

In this systematic review and meta-analysis of 35 studies involving 7,745 participants, high rates of serum estradiol change were associated with small increases in body mass index. Moderate to high rates of change were associated with decreases in low-density lipoprotein. Low rates of change were associated with small decreases in systolic blood pressure. Rate of serum estradiol change in adults using gender-affirming estrogen therapy may influence cardiovascular risk factors, though further research is warranted.

Association between serum estradiol and cardiovascular health among transgender adults using gender-affirming estrogen therapy Journal Articles