This study is a conceptual replication of an existing large study (N = 507) on the surface-based morphometric correlates of Five-Factor Model (FFM) personality traits. Using another large sample drawn from the same population (N = 597), results were aggregated from both samples (N = 1104), providing the largest investigation into the neuroanatomical correlates of FFM personality traits to date. Multiple clusters of significant brain by personality associations were found in the aggregate sample, including one for Openness with cortical thickness in the left and right dorsolateral prefrontal cortex (DLPFC), one for Agreeableness with thickness in the left DLPFC, and one for Agreeableness with area and volume in the right DLPFC. Clusters were also found for Neuroticism with cortical surface area in the right DLPFC, for Neuroticism with cortical thickness in the DLPFC and medial prefrontal cortex, and for Neuroticism with area and volume in the cuneus. While many regions found in the prior study were confirmed in the new and full samples, others were not, highlighting the challenges in replicating even high-quality, well-powered studies. As a whole, the current results provide the strongest evidence to date on the neuroanatomical correlates of personality.