Variability of polygenic prediction for body mass index in Africa

BackgroundPolygenic prediction studies in continental Africans are scarce. Africa’s genetic and environmental diversity pose a challenge that limits the generalizability of polygenic risk scores (PRS) for body mass index (BMI) within the continent. Studies to understand the factors that affect PRS variability within Africa are required.MethodsUsing the first multi-ancestry genome-wide association study (GWAS) meta-analysis for BMI involving …