Clinical efficacy of negative-pressure wound therapy with instillation of carboxymethyl chitosan bio-glue in diabetic foot ulcer

Objective To research the clinical efficacy of negative-pressure wound therapy with instillation of Carboxymethyl Chitosan Biological Glue in diabetic foot ulcer. Methods The study was prospective. A total of 60 patients with diabetic foot ulcers in Dongzhimen Hospital, Beijing University of Chinese Medicine were collected from February 2019 to March 2020. The patients were randomly divided into experimental group ( n =30) and control group ( n =30) according to the random number method. The control group was based on at the same time of treatment, normal saline drip irrigation was used for negative pressure therapy, and the experimental group was used for drip irrigation negative pressure therapy with carboxymethyl chitosan biological glue. The wound volume reduction value and the quantification and scoring criteria of the diabetic foot ulcer curative effect index were recorded in the two groups, and the t test and the rank sum test were used for statistical analysis. Results In the control group, there was 1 case of leakage in the negative pressure treatment, and finally a total of 59 patients completed and were included in the statistical data. After 14 days of treatment, the wound volume of patients in the experimental group was significantly better than that of the control group [9.00 (7.75, 12.00) ml vs. 5.00 (3.00, 6.00) ml, P <0.01]; the quantification of diabetic foot ulcer curative effect index and scoring in the experimentalgroup was smaller than that in the control group (16.96±1.74 vs. 20.40±7.06, P <0.05). There was no serious adverse events and reactions in the two groups. Conclusion Carboxymethyl chitosan bio-glue as a drip irrigation solution for negative pressure drip irrigation can promote diabetic foot ulcers, and the effect is better than normal saline.