Editors’ Choice—Challenges and Opportunities for Developing Electrochemical Biosensors with Commercialization Potential in the Point-of-Care Diagnostics Market

There is a plethora of electrochemical biosensors developed for ultrasensitive detection of clinically relevant biomarkers. However, many of these systems lose their performance in heterogeneous clinical samples and are too complex to be operated by end users at the point-of-care (POC), prohibiting their commercial success. Integration of biosensors with sample processing technology addresses both of these challenges; however, it adds to the manufacturing complexity and the overall cost of these systems. Herein, we review the different components of a biosensor and avenues for creating fully integrated systems. In the context of integration, we focus on discussing the trade-offs between sensing performance, cost, and scalable manufacturing to guide the readers toward designing new electrochemical biosensors with commercialization potential. Highlights Electrochemical biosensors are promising platforms for point-of-care diagnostics. Commercialized glucose sensors inspire other electrochemical biosensors. Scalable manufacturing of electrochemical chips and bioreceptors is essential. Integrating lab-based sample preparation with electrochemical biosensors is critical.