Journal article
Human platelets contain a pool of free zinc in dense granules
Abstract
Background: Activated platelets release procoagulant factors that include Ca2+ and Zn2+. Releasable Ca2+ stores have been identified in platelet dense granules and the dense tubular system, but similar stores of free Zn2+ have not been identified.
Objectives: Guided by studies of platelet Ca2+, we employed minimally disruptive methods to identify and localize concentrated free Zn2+ in human platelets.
Authors
Kahr WHA; Henderson SJ; Pluthero FG; Heijnen HFG; Vaezzadeh N; Stafford AR; Fredenburgh JC; Weitz JI
Journal
Research and Practice in Thrombosis and Haemostasis, Vol. 8, No. 2,
Publisher
Elsevier
Publication Date
2 2024
DOI
10.1016/j.rpth.2024.102352
ISSN
2475-0379