GRADE pearls and pitfalls—Part 1: Systematic reviews and meta‐analyses Journal Articles

abstract

• AbstractBackgroundThe Grading of Recommendation, Assessment, Development and Evaluation (GRADE) approach is used to assess the certainty of evidence in systematic reviews and meta‐analyses.MethodsWe describe how the GRADE approach is used in systematic reviews and meta‐analyses, including key points and examples. This overview is aimed at clinicians and researchers who are, or plan to be, involved in the development or assessment of systematic reviews with meta‐analyses using GRADE.ResultsWe outline how the certainty of evidence is assessed, how the evidence is summarized using GRADE evidence profiles or summary of findings tables, how the results are communicated, and we discuss challenges, advantages, and disadvantages with using GRADE.ConclusionsThis overview aims to provide an overview of how GRADE is used in systematic reviews and meta‐analyses, and may be used by systematic review developers, methodologists, and evidence end‐users.

authors

• Belley-Cote, Emilie
• Al Duhailib, Zainab
• Granholm, Anders
• Alhazzani, Waleed
• Oczkowski, Simon
• Belley‐Cote, Emilie
• Møller, Morten Hylander

status

• published 

publication date

• May 2024

has subject area

• 1103 Clinical Sciences (FoR)
• 1109 Neurosciences (FoR)
• 1116 Medical Physiology (FoR)
• Anesthesiology (Science Metrix)
• Evidence-Based Medicine (MeSH)
• Humans (MeSH)
• Meta-Analysis as Topic (MeSH)
• Review Literature as Topic (MeSH)
• Systematic Reviews as Topic (MeSH)

published in

• Acta Anaesthesiologica Scandinavica  Journal

keywords

• Evidence-Based Medicine
• GRADE
• Humans
• Meta-Analysis as Topic
• Review Literature as Topic
• Systematic Reviews as Topic
• meta‐analyses
• systematic reviews

Digital Object Identifier (DOI)

• 10.1111/aas.14386

PubMed ID

• 38351600

start page

• 584

end page

• 592

volume

• 68

issue

• 5