Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study Journal Articles uri icon

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abstract

  • AbstractPost-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

authors

  • Ozonoff, Al
  • Jayavelu, Naresh Doni
  • Liu, Shanshan
  • Melamed, Esther
  • Milliren, Carly E
  • Qi, Jingjing
  • Geng, Linda N
  • McComsey, Grace A
  • Cairns, Charles B
  • Baden, Lindsey R
  • Schaenman, Joanna
  • Shaw, Albert C
  • Samaha, Hady
  • Seyfert-Margolis, Vicki
  • Krammer, Florian
  • Rosen, Lindsey B
  • Steen, Hanno
  • Syphurs, Caitlin
  • Dandekar, Ravi
  • Shannon, Casey P
  • Sekaly, Rafick P
  • Ehrlich, Lauren IR
  • Corry, David B
  • Kheradmand, Farrah
  • Atkinson, Mark A
  • Brakenridge, Scott C
  • Higuita, Nelson I Agudelo
  • Metcalf, Jordan P
  • Hough, Catherine L
  • Messer, William B
  • Pulendran, Bali
  • Nadeau, Kari C
  • Davis, Mark M
  • Sesma, Ana Fernandez
  • Simon, Viviana
  • van Bakel, Harm
  • Kim-Schulze, Seunghee
  • Hafler, David A
  • Levy, Ofer
  • Kraft, Monica
  • Bime, Chris
  • Haddad, Elias K
  • Calfee, Carolyn S
  • Erle, David J
  • Langelier, Charles R
  • Eckalbar, Walter
  • Bosinger, Steven E
  • McEnaney, Kerry
  • Barton, Brenda
  • Lentucci, Claudia
  • Saluvan, Mehmet
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  • Hoch, Annmarie
  • Albert, Marisa
  • Shaheen, Tanzia
  • Kho, Alvin T
  • Thomas, Sanya
  • Chen, Jing
  • Murphy, Maimouna D
  • Cooney, Mitchell
  • Hayati, Arash Nemati
  • Bryant, Robert
  • Abraham, James
  • Presnell, Scott
  • Jancsyk, Tomasz
  • Maguire, Cole
  • Lee, Brian
  • Fourati, Slim
  • Esserman, Denise A
  • Guan, Leying
  • Gygi, Jeremy
  • Pawar, Shrikant
  • Brito, Anderson
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  • Wylie, Dennis
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  • Martens, Mark
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  • Mosier, Jarrod
  • Kimura, Hiroki
  • Khor, Bernard
  • Rahman, Adeeb
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  • Dutta, Jayeeta
  • Gonzalez-Reiche, Ana Silvia
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  • Carreño, Juan Manuel
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  • Raskin, Ariel
  • Tcheou, Johnstone
  • Bielak, Dominika
  • Kawabata, Hisaaki
  • Xie, Hui
  • Kelly, Geoffrey
  • Patel, Manishkumar
  • Nie, Kai
  • Yellin, Temima
  • Fried, Miriam
  • Sullivan, Leeba
  • Morris, Sara
  • Sieg, Scott
  • van Zalm, Patrick
  • Fatou, Benoit
  • Mendez, Kevin
  • Lasky-Su, Jessica
  • Hutton, Scott R
  • Michelotti, Greg
  • Wong, Kari
  • Jha, Meenakshi
  • Viode, Arthur
  • Kanarek, Naama
  • Petrova, Boryana
  • Zhao, Yujiao
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  • Tharp, Greg K
  • Pellegrini, Kathryn L
  • Beagle, Elizabeth
  • Cowan, David
  • Hamilton, Sydney
  • Ribeiro, Susan Pereira
  • Hodder, Thomas
  • Lee, Serena
  • Wilson, Michael R
  • Alvarenga, Bonny
  • Rajan, Jayant
  • Schroeder, Andrew W
  • Tsitsiklis, Alexandra
  • Mick, Eran
  • Guerrero, Yanedth Sanchez
  • Love, Christina
  • Maliskova, Lenka
  • Adkisson, Michael
  • Siles, Nadia
  • Geltman, Janelle
  • Hurley, Kerin
  • Saksena, Miti
  • Altman, Deena
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  • Roque, Jonasel
  • Yang, Samuel
  • Sigal, Natalia
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  • Harris, Paul
  • Consolo, Mary
  • Connors, Jennifer
  • Bernui, Mariana
  • Kutzler, Michele A
  • Edwards, Carolyn
  • Lee, Edward
  • Lin, Edward
  • Croen, Brett
  • Semenza, Nicholas C
  • Rogowski, Brandon
  • Melnyk, Nataliya
  • Woloszczuk, Kyra
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  • Furukawa, Sara
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  • Schearer, Pamela
  • Sheidy, Julie
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  • Nagle, Crystal
  • Smolen, Kinga
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  • Mitre, Xhoi
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  • Tong, Alexandra
  • Evans, Bethany
  • Montesano, Christina
  • Licona, Jose Humberto
  • Krauss, Jonathan
  • Chang, Jun Bai Park
  • Izaguirre, Natalie
  • Rooks, Rebecca
  • Elashoff, David
  • Brook, Jenny
  • Ramires-Sanchez, Estefania
  • Llamas, Megan
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  • Perdomo, Claudia
  • Ward, Dawn C
  • Magyar, Clara E
  • Fulcher, Jennifer A
  • Pickering, Harry C
  • Sen, Subha
  • Chaudhary, Omkar
  • Coppi, Andreas
  • Fournier, John
  • Mohanty, Subhasis
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  • Nelson, Allison
  • Raddassi, Khadir
  • Rainone, Michael
  • Ruff, William E
  • Salahuddin, Syim
  • Schulz, Wade L
  • Vijayakumar, Pavithra
  • Wang, Haowei
  • Wunder, Elsio
  • Young, H Patrick
  • Rothman, Jessica
  • Konstorum, Anna
  • Chen, Ernie
  • Cotsapas, Chris
  • Grubaugh, Nathan D
  • Wang, Xiaomei
  • Xu, Leqi
  • Asashima, Hiromitsu
  • Bristow, Laurel
  • Hussaini, Laila
  • Hellmeister, Kieffer
  • Wimalasena, Sonia Tandon
  • Cheng, Andrew
  • Spainhour, Christine
  • Scherer, Erin M
  • Johnson, Brandi
  • Bechnak, Amer
  • Ciric, Caroline R
  • Hewitt, Lauren
  • Carter, Erin
  • Mcnair, Nina
  • Panganiban, Bernadine
  • Huerta, Christopher
  • Usher, Jacob
  • Vaysman, Tatyana
  • Holland, Steven M
  • Abe-Jones, Yumiko
  • Asthana, Saurabh
  • Beagle, Alexander
  • Bhide, Sharvari
  • Carrillo, Sidney A
  • Chak, Suzanna
  • Ghale, Rajani
  • Gonzalez, Ana
  • Jauregui, Alejandra
  • Jones, Norman
  • Lea, Tasha
  • Lee, Deanna
  • Lota, Raphael
  • Milush, Jeff
  • Nguyen, Viet
  • Pierce, Logan
  • Prasad, Priya A
  • Rao, Arjun
  • Samad, Bushra
  • Shaw, Cole
  • Sigman, Austin
  • Sinha, Pratik
  • Ward, Alyssa
  • Willmore, Andrew
  • Zhan, Jenny
  • Rashid, Sadeed
  • Rodriguez, Nicklaus
  • Tang, Kevin
  • Altamirano, Luz Torres
  • Betancourt, Legna
  • Curiel, Cindy
  • Sutter, Nicole
  • Paz, Maria Tercero
  • Tietje-Ulrich, Gayelan
  • Leroux, Carolyn
  • Thakur, Neeta
  • Vasquez, Joshua J
  • Santhosh, Lekshmi
  • Song, Li-Zhen
  • Nelson, Ebony
  • Moldawer, Lyle L
  • Borresen, Brittany
  • Roth-Manning, Brittney
  • Ungaro, Ricardo F
  • Oberhaus, Jordan
  • Booth, J Leland
  • Sinko, Lauren A
  • Brunton, Amanda
  • Sullivan, Peter E
  • Strnad, Matthew
  • Lyski, Zoe L
  • Coulter, Felicity J
  • Micheleti, Courtney
  • Conway, Michelle
  • Francisco, Dave
  • Molzahn, Allyson
  • Erickson, Heidi
  • Wilson, Connie Cathleen
  • Schunk, Ron
  • Sierra, Bianca
  • Hughes, Trina
  • Peters, Bjoern
  • Kleinstein, Steven H
  • Reed, Elaine F
  • Augustine, Alison D
  • Diray-Arce, Joann
  • Maecker, Holden T
  • Altman, Matthew C
  • Montgomery, Ruth R
  • Becker, Patrice M
  • Rouphael, Nadine

publication date

  • January 3, 2024