Imaging modalities: Fluoroscopy and ultrasound are the most commonly used modalities for image-guided interventions of the ankle and foot. Fluoroscopy continues to be the modality of choice for injecting the ankle joint, posterior subtalar joint, and small joints of the midfoot, despite the radiation involved with this procedure. This is due to the ease and rapidity of the procedure and due to excellent joint and bone visualization for needle guidance. However, in some centers, these joints are injected under ultrasound guidance as ultrasound is easily accessible. Ultrasound provides excellent resolution of superficial soft tissues, dynamic vision of the soft tissue target, and needle tip localization. It is the modality of choice for soft tissue interventions, be it tendon, ligament, nerve, bursa, or plantar fascia. MR guided perineural injections are uncommon and are undertaken in a few academic centers. The injectables for these procedures include local anesthetics that are utilized for performing diagnostic blocks, intra-articular steroid injections, steroid injections into bursae and perineural areas, autologous blood or PRP injections into joints, tendons, ligaments, neuromas, plantar fascia, hyaluronic acid into joints, and gadolinium injection into the ankle joint for MR arthrography. US-guided soft tissue/bone biopsies and foreign body removal are described briefly, as these techniques are similar to the rest of the body. Each intervention will be dealt with separately for easy comprehension and for day-to-day application by the reader.