Journal article
Chronic TNF in the Aging Microenvironment Exacerbates TET2-loss-of-Function Myeloid Expansion
Abstract
Introduction: Age-associated TET2 somatic mutations impart an intrinsic hematopoietic stem cell (HSC) advantage and contribute to the phenomenon of clonal hematopoiesis of indeterminate potential (CHIP). Individuals with TET2-mutantCHIP have a higher risk of developing myeloid neoplasms and other age-related conditions, including heart, lung, liver, kidney and infectious disease, and have increased risk of all-cause mortality. Despite its role …
Authors
Quin C; DeJong E; McNaughton AJM; Buttigieg MM; Basrai S; Abelson S; Larche M; Rauh MJ; Bowdish DM
Journal
Blood, Vol. 142, No. Supplement 1,
Publisher
American Society of Hematology
Publication Date
November 2, 2023
DOI
10.1182/blood-2023-189163
ISSN
0006-4971