Abstract A109: Targeting pyrimidine biosynthesis as a metabolic vulnerability in brain metastasis

Abstract Metastasis, the spread of cancer cells from one part of the body to another, is the leading cause of death among cancer patients. Lung-to-Brain metastasis remains a largely understudied disease that possesses a dismal prognosis due to the lack of effective therapies. We previously identified purine metabolism as a metabolic vulnerability of brain metastases.  Here, we sought to identify whether pyrimidine biosynthesis is also a …