Journal article
PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease
Abstract
BACKGROUND: Epidemiological evidence links the proprotein convertase subtilisin/kexin 7 (PCSK7) to triglyceride (TG) metabolism. We associated the known PCSK7 gain-of-function non-coding SNP rs236918 with higher levels of plasma apolipoprotein B (apoB) and the loss-of-function coding variant p.Pro777Leu (SNP rs201598301) with lower apoB and TG. Herein, we aimed to unravel the in vivo role of liver PCSK7.
METHODS: We biochemically defined the …
Authors
Sachan V; Le Dévéhat M; Roubtsova A; Essalmani R; Laurendeau J-F; Garçon D; Susan-Resiga D; Duval S; Mikaeeli S; Hamelin J
Journal
Metabolism, Vol. 150, ,
Publisher
Elsevier
Publication Date
January 2024
DOI
10.1016/j.metabol.2023.155736
ISSN
0026-0495