Resource use and cost associated with computerized decision support system and usual care in managing patients with atrial fibrillation: analysis of IMPACT-AF randomized trial data Journal Articles uri icon

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  • Abstract Background IMPACT-AF is a prospective, randomized, cluster design trial comparing atrial fibrillation (AF) management with a computerized decision support system (CDS) to usual care (control) in the primary care setting of Nova Scotia, Canada. The objective of this analysis was to compare the resource use and costs between CDS and usual care groups. Methods Case costing data, 12-month self-administered questionnaires, and monthly diaries from IMPACT-AF were used in this analysis. Descriptive statistics were used to compare costs and resource use between groups. All costs are presented in 2021 Canadian dollars and cover the 12-month period of participation in the study. Results A total of 1,145 patients enrolled in the trial. Case costing data were available for 466 participants (41.1%), 12-month self-administered questionnaire data for 635 participants (56.0%) and monthly diary data for 223 participants (19.7%). Emergency department visits and hospitalizations comprised the most expensive component of AF care. Across all three datasets, there were no statistically significant differences in costs or resource use between CDS and usual care groups. Conclusions Although there were no significant differences in resource use or costs among CDS and usual care groups in the IMPACT-AF trial, this study provides insight into the methodology and practical challenges of collecting economic data alongside a trial. Registration (registration number: NCT01927367, date of registration: 2013-08-20).


  • Humphries, Brittany
  • Cox, Jafna L
  • Parkash, Ratika
  • Thabane, Lehana
  • Foster, Gary A
  • MacKillop, James
  • Nemis-White, Joanna
  • Hamilton, Laura
  • Ciaccia, Antonio
  • Choudhri, Shurjeel H
  • Kovic, Bruno
  • Xie, Feng

publication date

  • October 18, 2023