Journal article
Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity
Abstract
Knowledge of the transcriptional programs underpinning the functions of human kidney cell populations at homeostasis is limited. We present a single-cell perspective of healthy human kidney from 19 living donors, with equal contribution from males and females, profiling the transcriptome of 27677 cells to map human kidney at high resolution. Sex-based differences in gene expression within proximal tubular cells were observed, specifically, …
Authors
McEvoy CM; Murphy JM; Zhang L; Clotet-Freixas S; Mathews JA; An J; Karimzadeh M; Pouyabahar D; Su S; Zaslaver O
Journal
Nature Communications, Vol. 13, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-022-35297-z
ISSN
2041-1723