Journal article
A novel multi-ancestry proteome-wide Mendelian randomization study implicates extracellular proteins, tubular cells, and fibroblasts in estimated glomerular filtration rate regulation
Abstract
Estimated glomerular filtration rate (eGFR) impacts the concentration of plasma biomarkers confounding biomarker association studies of eGFR with reverse causation. To identify biomarkers causally associated with eGFR, we performed a proteome-wide Mendelian randomization study. Genetic variants nearby biomarker coding genes were tested for association with plasma concentration of 1,161 biomarkers in a multi-ancestry sample of 12,066 …
Authors
Lanktree MB; Perrot N; Smyth A; Chong M; Narula S; Shanmuganathan M; Kroezen Z; Britz-Mckibbin P; Berger M; Krepinsky JC
Journal
Kidney International, Vol. 104, No. 6, pp. 1170–1184
Publisher
Elsevier
Publication Date
December 2023
DOI
10.1016/j.kint.2023.08.025
ISSN
0085-2538