Toward a molecular mechanism for the interaction of ATP with alpha-synuclein Journal Articles uri icon

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abstract

  • We propose a mechanism for the hydrotrope-like function of ATP on alpha-synuclein whereby ATP enhances initial αS aggregation and inhibits fibril formation in a phosphate-dependent manner that is modulated by PD-related αS mutations E46K and A53T.

publication date

  • September 20, 2023