Journal article
Propranolol Normalizes Metabolomic Signatures Thereby Improving Outcomes After Burn
Abstract
OBJECTIVE AND BACKGROUND: Propranolol, a nonselective beta-receptor blocker, improves outcomes of severely burned patients. While the clinical and physiological benefits of beta-blockade are well characterized, the underlying metabolic mechanisms are less well defined. We hypothesized that propranolol improves outcomes after burn injury by profoundly modulating metabolic pathways.
METHODS: In this phase II randomized controlled trial, patients …
Authors
Rehou S; de Brito Monteiro L; Auger C; Knuth CM; Abdullahi A; Stanojcic M; Jeschke MG
Journal
Annals of Surgery, Vol. 278, No. 4, pp. 519–529
Publisher
Wolters Kluwer
Publication Date
10 2023
DOI
10.1097/sla.0000000000005973
ISSN
0003-4932