Montelukast in childhood asthma: what is the evidence for its use?
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Asthma is a complex process involving extensive infiltration of the airway mucosa and lumen by activated inflammatory cells and release of mediators that result in airway inflammation and bronchoconstriction. Leukotrienes are mediators believed to play a major role in this process. At present, inhaled corticosteroids are the cornerstone of asthma management. However, asthma control may remain suboptimal and there is well-documented concern regarding adverse events with the use of inhaled corticosteroids in children. Leukotriene receptor antagonists, such as montelukast, provide a safe and effective treatment option with ease of administration, particularly in preschool children and as add-on therapy in patients with difficult-to-control asthma.
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