This chapter discusses key transdiagnostic cognitive, behavioral, and physiological features of anxiety disorders and how these may be targeted using exposure therapy. Benefits of transdiagnostic and disorder-specific approaches to treating anxiety disorders are discussed, as well as considerations for when one may want to use each approach. Guidelines for how to deviate from typical disorder-specific approaches are provided, in the context of both individual and group treatments for anxiety disorders. A brief review of the literature is provided, as well as a case example to illustrate the application of transdiagnostic exposure therapy for comorbid anxiety disorders.