Successful Treatment of Nephrotic Syndrome Due to Collapsing Focal Segmental Glomerulosclerosis Accompanied by Acute Interstitial Nephritis Journal Articles uri icon

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  • A 39-year-old woman was hospitalized for nephrotic syndrome. Laboratory test results showed increased serum creatinine levels and urinary excretions of beta-2-microglobulin, and N-acetyl-beta-D-glucosaminidase. A renal biopsy revealed collapsing focal segmental glomerulosclerosis (FSGS) and acute interstitial nephritis. Despite treatment with pulse steroid followed by oral high-dose glucocorticoids and cyclosporines, heavy proteinuria persisted. After low-density lipoprotein apheresis (LDL-A) therapy was initiated, her proteinuria gradually decreased, leading to complete remission. A repeat renal biopsy after treatment revealed no collapsing glomeruli. Immediate LDL-A should be performed to treat cases of collapsing FSGS poorly responding to other treatments.


  • Shima, Hisato
  • Doi, Toshio
  • Okamoto, Takuya
  • Higashiguchi, Yusuke
  • Harada, Megumi
  • Inoue, Tomoko
  • Tashiro, Manabu
  • Wariishi, Seiichiro
  • Takamatsu, Norimichi
  • Kawahara, Kazuhiko
  • Okada, Kazuyoshi
  • Minakuchi, Jun

publication date

  • June 15, 2022