Discussion Mammalian Cell Killing by Inhibitors of DNA Synthesis

During the course of his discussion this afternoon, Dr. Philips mentioned two agents, hydroxyurea and cytosine arabinoside which appeared to bring about rapid destruction of the cells of the intestinal lining. Like a number of other groups we have been interested in the effects of these compounds and others on mammalian cells in tissue culture. In agreement with the observation of Dr. Philips and others (1, 2, 3) we have observed that with …