keywords 4 RECOMBINANT ISOFORMS BEE VENOM IMMUNOTHERAPY DUST MITE ALLERGEN GRASS-POLLEN ALLERGOIDS GROWTH-FACTOR-BETA Life Sciences & Biomedicine MESSENGER-RNA EXPRESSION MYELIN BASIC-PROTEIN PLACEBO-CONTROLLED IMMUNOTHERAPY Pharmacology & Pharmacy Respiratory System SITE-DIRECTED MUTAGENESIS Science & Technology T-CELL RESPONSES