A novel synthesis of nor-C-statine.

Abstract

A new synthesis of nor-C-statine is described. Benzylation of a malate dianion, differentiation of the two carboxylates and a Hofmann degradation of one of the carboxylates constitute the key steps of the synthesis.

Authors

Dugger RW; Ralbovsky JL; Bryant D; Commander J; Massett SS; Sage NA; Selvidio JR

Journal

Tetrahedron Letters, Vol. 33, No. 45, pp. 6763–6766

Publisher

Elsevier

Publication Date

November 3, 1992

DOI

10.1016/s0040-4039(00)61770-7

ISSN

0040-4039

Associated Experts

Dianne Bryant

Associate Professor (Part-Time), Faculty of Health Sciences

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Labels

Fields of Research (FoR)

3405 Organic chemistry 34 Chemical Sciences 3101 Biochemistry and cell biology 3404 Medicinal and biomolecular chemistry

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