Analysis of tRNAs during the development of Drosophila

Conditions for the chromatography of radioactively labeled Drosophila aminoacyl-tRNAs on reversed-phase 5 columns have been established. All 20 aminoacyl-tRNAs from first instar, third instar, and adult flies were compared. While some of the aminoacyl-tRNAs remain essentially unchanged during the development of Drosophila, others show marked quantitative changes. These changes are discussed in relation to possible control mechanisms during development.