Oligoribonucleotide Synthesis. II. Preparation of 2-O-tetrahydropyranyl Derivatives of Adenosine and Cytidine Necessary for Insertion in Stepwise Synthesis

The syntheses of N 6 -benzoyl-2′-O-tetrahydropyranyladenosine (2) and N 4 -benzoyl-2′-O-tetrahydropyranylcytidine (11) and their corresponding 5′-O-p-methoxytrityl derivatives, 3 and 12 respectively, are described. Compounds 2, 3, 11, and 12 are the protected derivatives of adenosine and cytidine required for insertion into a new oligoribonucleotide synthesis. Compound 2 was prepared from the known 2′-O-tetrahydropyranyladenosine by …