Empirical progression criteria thresholds for feasibility outcomes in HIV clinical trials: a methodological study

IntroductionPilot and feasibility trials use predetermined thresholds for feasibility outcomes to decide if a larger trial is feasible. These thresholds may be derived from the literature, observational data, or clinical experience. The aim of this study was to determine empirical estimates for feasibility outcomes to inform future HIV pilot randomized trials.MethodsWe conducted a methodological study of HIV clinical trials indexed in the past …