Differences in hyperpolarized 3He ventilation imaging after 4 years in adults with cystic fibrosis Journal Articles uri icon

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abstract

  • PurposeTo evaluate cystic fibrosis (CF) subjects over 4 years using 3He magnetic resonance imaging (MRI), pulmonary function tests, and track hospitalization and physician visits.Materials and MethodsFive CF adults provided written informed consent to an approved protocol and underwent MRI, spirometry, and plethysmography at baseline, 7 days, and 4 ± 1 years later. 3He MRI ventilation defect percent (VDP) was generated for all subjects and timepoints.ResultsAfter 4 years, mean forced expiratory volume in 1 second / forced vital capacity (FEV1/FVC) was lower (P = 0.01) in all subjects and there were no other pulmonary function test changes. Two CF adults showed significantly elevated (worse) 3He VDP at baseline and after 4 years they had significantly greater (worsened) VDP (P = 0.02), without a significant FEV1 decline (P = 0.06) but with a greater number of exacerbations (P < 0.05). Baseline VDP strongly correlated with FEV1 (r2 = 0.98, P = 0.0007) at 4‐year follow‐up.ConclusionFor two CF subjects, VDP was significantly worse at baseline and worsened over 4 years, which was in agreement with a greater number of hospitalizations and clinic visits. These results are limited by the very small sample size, but the strong VDP correlation with longitudinal changes in FEV1 generates the hypothesis that abnormal VDP may temporally precede FEV1 decline in CF subjects; this must be tested in a larger CF study. J. Magn. Reson. Imaging 2015;41:1701–1707. © 2014 Wiley Periodicals, Inc.

authors

  • Paulin, Gregory A
  • Svenningsen, Sarah
  • Jobse, Brian N
  • Mohan, Sindu
  • Kirby, Miranda
  • Lewis, James F
  • Parraga, Grace

publication date

  • June 2015