Journal article
Association of Low-Dose Colchicine With Incidence of Knee and Hip Replacements : Exploratory Analyses From a Randomized, Controlled, Double-Blind Trial.
Abstract
BACKGROUND: Osteoarthritis is a major contributor to pain and disability worldwide. Given that inflammation plays an important role in the development of osteoarthritis, anti-inflammatory drugs may slow disease progression.
OBJECTIVE: To examine whether colchicine, 0.5 mg daily, reduces incident total knee replacements (TKRs) and total hip replacements (THRs).
Authors
Heijman MWJ; Fiolet ATL; Mosterd A; Tijssen JGP; van den Bemt BJF; Schut A; Eikelboom JW; Thompson PL; van den Ende CHM; Nidorf SM
Journal
Annals of Internal Medicine, Vol. 176, No. 6, pp. 737–742
Publisher
American College of Physicians
Publication Date
June 2023
DOI
10.7326/m23-0289
ISSN
1056-8751