Preprint
Expression of miRNA-29 in Pancreatic β-Cells Promotes Inflammation and Diabetes Via TRAF3
Abstract
Type 2 diabetes mellitus (T2DM) is recognized as a chronic low-grade inflammatory disease characterized by insulin resistance and pancreatic β-cell dysfunction; however, the underlying molecular mechanism remains unclear. Here, we report a new β-cell–macrophage crosstalk pathway mediated by the “miRNA-29-TNF receptor-associated factor 3 (TRAF3)” axis. β-cell specific transgenic miR-29a/b-1 mice are predisposed to develop glucose intolerance and …
Authors
Sun Y; Zhou Y; Shi Y; Zhang Y; Liu K; Liang R; Sun P; Chang X; Tang W; Zhang Y
Publication date
January 1, 2020
DOI
10.2139/ssrn.3640673
Preprint server
SSRN Electronic Journal