Preprint
Inflammation promotes adipocyte lipolysis via IRE1 kinase
Abstract
Abstract Obesity associates with inflammation, insulin resistance and higher blood lipids. It is unclear if immune responses facilitate lipolysis separate from hormone or adrenergic signals. We found that an ancient component of ER stress, inositol-requiring protein 1 (IRE1), discriminates inflammation-induced adipocyte lipolysis versus lipolysis regulated by adrenergic or hormonal stimuli. Inhibiting IRE1 kinase activity was sufficient to …
Authors
Foley KP; Chen Y; Barra NG; Heal M; Kwok K; Tamrakar AK; Chi W; Duggan BM; Henriksbo BD; Liu Y
DOI
10.1101/2020.04.07.030148
Preprint server
bioRxiv