Journal article
A multi-specific, multi-affinity antibody platform neutralizes sarbecoviruses and confers protection against SARS-CoV-2 in vivo
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has been responsible for a global pandemic. Monoclonal antibodies (mAbs) have been used as antiviral therapeutics; however, these therapeutics have been limited in efficacy by viral sequence variability in emerging variants of concern (VOCs) and in deployment by the need for high doses. In this study, we leveraged the …
Authors
Burn Aschner C; Muthuraman K; Kucharska I; Cui H; Prieto K; Nair MS; Wang M; Huang Y; Christie-Holmes N; Poon B
Journal
Science Translational Medicine, Vol. 15, No. 697,
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
May 24, 2023
DOI
10.1126/scitranslmed.adf4549
ISSN
1946-6234