Preprint
Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers
Abstract
Abstract Background Epidemiological studies have reported conflicting findings on the potential adverse effects of long-term antihypertensive medication use on cancer risk. Naturally occurring variation in genes encoding antihypertensive drug targets can be used as proxies for these targets to examine the effect of their long-term therapeutic inhibition on disease outcomes. Methods Single-nucleotide polymorphisms (SNPs) in ACE , ADRB1 , and …
Authors
Yarmolinsky J; Díez-Obrero V; Richardson TG; Pigeyre M; Sjaarda J; Paré G; Walker VM; Vincent EE; Tan VY; Obón-Santacana M
DOI
10.1101/2021.03.11.21252971
Preprint server
medRxiv