Patient-important outcomes reported in clinical studies of pharmacologic treatments for covid-19: A protocol of a meta-epidemiological study

ABSTRACTBackground: The coronavirus disease 19 (covid-19) pandemic has underscored the need to expedite clinical research, which may lead investigators to shift away from measuring patient-important outcomes (PIOs), limiting research applicability. We aim to describe the extent to which randomized controlled trials (RCTs) of covid-19 therapies will determine PIOs. Methods: We will perform a meta-epidemiological study of RCTs that included …