Genome-Wide Polygenic Risk Scores and Prediction of Gestational Diabetes in South Asian Women

ABSTRACT Gestational diabetes Mellitus (GDM) affects 1 in 7 births and is associated with numerous adverse health outcomes for both mother and child. GDM is suspected to share a large common genetic background with type 2 diabetes (T2D). The first aim of this study, was to characterize different GDM polygenic risk scores (PRSs) using data from the South Asian Birth Cohort (START). The second aim of this study was to estimate the …