Severe burn patients are characterized by a prolonged and persistent hypermetabolic response that leads to muscle wasting, hyperglycemia, and severe cachexia. Inadequate nutritional supplementation to help meet the increased energy requirements can result in multiorgan failure, impaired wound healing, increased infection rates, longer hospital stays, and poor patient outcome. Thus, nutritional supplementation is vital to patient recovery and to attenuate the hypermetabolic response and its associated consequences. Here, we provide nutritional recommendations gained from clinical trials, retrospective analyses, and finally expert opinions based on our practice at the Ross Tilley Burn Center. We also provide an insight to the type of nutritional support, its timing, route of administration, and its role in the recuperation of burn patients.