Journal article
Effect of Human Wharton's Jelly Mesenchymal Stem Cell Paracrine Signaling on Keloid Fibroblasts
Abstract
Keloid scars are abnormal benign fibroproliferative tumors with high recurrence rates and no current efficacious treatment. Accumulating evidence suggests that human umbilical cord Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) have antifibrotic properties. Paracrine signaling is considered one of the main underlying mechanisms behind the therapeutic effects of mesenchymal stem cells. However, the paracrine signaling effects of …
Authors
Arno AI; Amini-Nik S; Blit PH; Al-Shehab M; Belo C; Herer E; Jeschke MG
Journal
Stem Cells Translational Medicine, Vol. 3, No. 3, pp. 299–307
Publisher
Oxford University Press (OUP)
Publication Date
March 1, 2014
DOI
10.5966/sctm.2013-0120
ISSN
2157-6564
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Cell ProliferationCoculture TechniquesCulture Media, ConditionedDiffusion Chambers, CultureFetal BloodFibroblastsGene Expression RegulationHumansInterleukin-6Interleukin-8KeloidMesenchymal Stem CellsParacrine CommunicationPlasminogen Activator Inhibitor 1Primary Cell CultureTransforming Growth Factor beta1Transforming Growth Factor beta2Transforming Growth Factor beta3Wharton Jelly