Neutrophils from burn patients suppress the beta‐defensin production by human epidermal keratinocytes

Recently, we have isolated immunosuppressive neutrophils (PMN‐II) from patients with severe thermal injuries. PMN‐II play a role on the increased susceptibility of burn hosts to various infections. Since antimicrobial peptides have been described as important effector molecules on host antimicrobial innate immunities, in the present study, the influence of PMN‐II on the beta‐defensins (BD) production by human keratinocytes has been studied. …