Today, there are approximately 40 million people in the United States over the age of 65. As the population ages, this figure is projected to drastically increase to nearly 90 million by the year 2050. With this in mind, as the elderly population increases, it is expected that the incidence of elderly burn victims will as well. This chapter provides insight into the epidemiology, prognosis, and physical considerations in the management and treatment of elderly burn patients. Furthermore, it will explore the acute phase response after burn injury, infections and sepsis, and long-term outcomes. Thermal injuries have a unique manifestation relative to other forms of trauma, and the following sections will demonstrate that this creates further difficulties in older adults. The growing body of literature in elderly burn patients in the last decade reflects the inherent challenges when treating and also sheds light on the demand for improved therapeutic regimes for this growing population.