Allogeneic mesenchymal stem cells for treatment of severe burn injury Journal Articles

abstract

• AbstractThe most important determinant of survival post-burn injury is wound healing. For decades, allogeneic mesenchymal stem cells (MSCs) have been suggested as a potential treatment for severe burn injuries. This report describes a patient with a severe burn injury whose wounds did not heal with over 18 months of conventional burn care. When treated with allogeneic MSCs, wound healing accelerated with no adverse treatment complications. Wound sites showed no evidence of keloids or hypertrophic formation during a 6-year follow-up period. This therapeutic use of allogeneic MSCs for large non-healing burn wounds was deemed safe and effective and has great treatment potential.

authors

• Jeschke, Marc
• Rehou, Sarah
• McCann, Matthew R
• Shahrokhi, Shahriar

status

• published 

publication date

• December 2019

has subject area

• 06 Biological Sciences (FoR)
• 10 Technology (FoR)
• 11 Medical and Health Sciences (FoR)
• Adult (MeSH)
• Allografts (MeSH)
• Burns (MeSH)
• Humans (MeSH)
• Male (MeSH)
• Mesenchymal Stem Cell Transplantation (MeSH)
• Trauma Severity Indices (MeSH)
• Wound Healing (MeSH)

published in

• Stem Cell Research and Therapy  Journal

keywords

• Adult
• Allografts
• Burns
• Cell therapy
• Humans
• Male
• Mesenchymal Stem Cell Transplantation
• Mesenchymal stem cells
• Trauma Severity Indices
• Wound Healing
• Wound healing

Digital Object Identifier (DOI)

• 10.1186/s13287-019-1465-9

start page

• 337

volume

• 10

issue

• 1