Elevated Cerebrospinal Fluid Glutamate in Patients With HIV-related Dementia

To the Editor. —The intriguing possibility that glutamate-mediated neuronal toxicity is implicated in dementia related to acquired immunodeficiency syndrome (AIDS) has gained increasing interest in recent years. The new findings of Dr Ferrarese and coworkers1 on elevated glutamate levels in AIDS patients' cerebrospinal fluid (CSF) accentuate this issue and raise hopes that glutamate antagonists may be developed as potential neuroprotective …